Pentobarbital increases toxicity of methoxyflurane by rising metabolism. Contraindicated. Increased metabolism of methoxyflurane to nephrotoxic compounds. pentobarbital will lower the extent or outcome of phenytoin by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Observe. pentobarbital increases toxicity of buprenorphine, long-performing injection by pharmacodynamic syner... https://finndaoyh.blogunteer.com/30285889/getting-my-is-nembutal-a-depressant-to-work